Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …

There are more than 70 distinct sarcomas, and this diversity complicates the development of
precision-based therapeutics for these cancers. Prospective comprehensive genomic …

Objective Osteosarcoma (OS) is a common bone malignancy with poor prognosis. We
aimed to investigate the relationship between cuproptosis-related lncRNAs (CRLncs) and …

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …

Simple Summary Osteosarcoma is the most common malignant bone tumor in children, with
a 5-year survival rate ranging from 70% to 20% depending on the aggressiveness of the …

The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation
of immune tolerance mechanisms in the osteosarcoma microenvironment and a new …

Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet
dogs. To define the genomic underpinnings of canine OS, we performed multi-platform …

Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …

Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class
of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to …