Identification of 5 potential predictive biomarkers for Alzheimer's disease by integrating the unified test for molecular signatures and weighted gene coexpression …
S Zhou, G Ma, H Luo, S Shan, J Xiong… - The Journals of …, 2023 - academic.oup.com
Background Previous transcriptome-wide association study (TWAS) has documented 21
genes associated with Alzheimer's disease (AD) risk, but the predictive biomarkers remain …
genes associated with Alzheimer's disease (AD) risk, but the predictive biomarkers remain …
Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements
Most genetic variants associated with psychiatric disorders are located in noncoding regions
of the genome. To investigate their functional implications, we integrate epigenetic data from …
of the genome. To investigate their functional implications, we integrate epigenetic data from …
[HTML][HTML] Pyroptosis as a candidate therapeutic target for Alzheimer's disease
Y Huang, X Li, G Luo, J Wang, R Li, C Zhou… - Frontiers in Aging …, 2022 - frontiersin.org
Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the
relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing …
relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing …
The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies
Human genetics studies of Alzheimer's disease (AD) have identified the ABI3 gene as a
candidate risk gene for AD. Because ABI3 is highly expressed in microglia, the brain's …
candidate risk gene for AD. Because ABI3 is highly expressed in microglia, the brain's …
Neuroepigenetic mechanisms of action of ultrashort peptides in Alzheimer's disease
A Ilina, V Khavinson, N Linkova… - International Journal of …, 2022 - mdpi.com
Epigenetic regulation of gene expression is necessary for maintaining higher-order
cognitive functions (learning and memory). The current understanding of the role of …
cognitive functions (learning and memory). The current understanding of the role of …
Role of adaptin protein complexes in intracellular trafficking and their impact on diseases
Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical'role of
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …
Novel genetic variants in TP37, PIK3R1, CALM1, and PLCG2 of the neurotrophin signaling pathway are associated with the progression from mild cognitive …
Background: Alzheimer's disease (AD) is a common neurodegenerative disease and mild
cognitive impairment (MCI) is considered as the prodromal stage of AD. Previous studies …
cognitive impairment (MCI) is considered as the prodromal stage of AD. Previous studies …
Differential Gene Expression in Activated Microglia Treated with Adenosine A2A Receptor Antagonists Highlights Olfactory Receptor 56 and T-Cell Activation GTPase …
Microglial activation often accompanies the plastic changes occurring in the brain of patients
with neurodegenerative diseases. A2A and A3 adenosine receptors have been proposed as …
with neurodegenerative diseases. A2A and A3 adenosine receptors have been proposed as …
Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics
K Leng, M Kampmann - Genome Medicine, 2022 - Springer
Our understanding of neurological diseases has been tremendously enhanced over the past
decade by the application of new technologies. Genome-wide association studies have …
decade by the application of new technologies. Genome-wide association studies have …
Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes
Advances and reduction of costs in various sequencing technologies allow for a closer look
at variations present in the non-coding regions of the human genome. Correlating non …
at variations present in the non-coding regions of the human genome. Correlating non …