Neurodegenerative dementia can result from multiple underlying abnormalities, including
neurotransmitter imbalances, protein aggregation, and other neurotoxic events. A major …

With the ongoing demographic shift towards increasingly elderly populations, it is estimated
that approximately 150 million people will live with Alzheimer's disease (AD) by 2050. By …

Alzheimer's disease (AD) is a prototypical inflammation-associated loss of cognitive function,
with approximately 90% of the AD burden associated with invading myeloid cells controlling …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects over 50
million elderly individuals worldwide. Although the pathogenesis of AD is not fully …

Since their discovery 15 years ago, human pluripotent stem cell (hPSC) technologies have
begun to revolutionize science and medicine, rapidly expanding beyond investigative …

Background Tauopathies are a group of neurodegenerative diseases driven by abnormal
aggregates of tau, a microtubule associated protein encoded by the MAPT gene. MAPT …

Genome-wide association studies (GWASs) have uncovered over 75 genomic loci
associated with risk for late-onset Alzheimer's disease (LOAD), but identification of the …

Multiple psychiatric disorders have been associated with abnormalities in both the innate
and adaptive immune systems. The role of these abnormalities in pathogenesis, and …

Image genetics mainly explores the pathogenesis of Alzheimer's disease (AD) by studying
the relationship between genetic data (such as SNP, gene expression data, and DNA …

Background Myeloid cells, including monocytes, macrophages, microglia, dendritic cells and
neutrophils are a part of innate immunity, playing a major role in orchestrating innate and …