[HTML][HTML] Proteomics applications in health: biomarker and drug discovery and food industry

N Amiri-Dashatan, M Koushki… - Iranian journal of …, 2018 - ncbi.nlm.nih.gov
Advancing in genome sequencing has greatly propelled the understanding of the living
world; however, it is insufficient for full description of a biological system. Focusing on …

The function of immunoproteasomes—an immunologists' perspective

BL van den Eshof, L Medfai, E Nolfi, M Wawrzyniuk… - Cells, 2021 - mdpi.com
Proteasomes are responsible for intracellular proteolysis and play an important role in
cellular protein homeostasis. Cells of the immune system assemble a specialized form of …

[HTML][HTML] Protein-protein interaction analysis of Alzheimers disease and NAFLD based on systems biology methods unhide common ancestor pathways

R Karbalaei, M Allahyari… - … and Hepatology from …, 2018 - ncbi.nlm.nih.gov
Aim: Analysis reconstruction networks from two diseases, NAFLD and Alzheimers diseases
and their relationship based on systems biology methods. Background: NAFLD and …

[HTML][HTML] Protein-protein interaction network analysis for a biomarker panel related to human esophageal adenocarcinoma

M Rezaei-Tavirani, S Rezaei-Tavirani… - Asian Pacific journal …, 2017 - ncbi.nlm.nih.gov
Background: Esophageal adenocarcinoma (EAC) is one of the mostlethal cancers in the
world with a very poor prognosis. Identification of molecular diagnostic methods is an …

Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis

N Safari-Alighiarloo, M Rezaei-Tavirani, M Taghizadeh… - PeerJ, 2016 - peerj.com
Background The involvement of multiple genes and missing heritability, which are dominant
in complex diseases such as multiple sclerosis (MS), entail using network biology to better …

Prevalence of inflammatory pathways over immuno-tolerance in peripheral blood mononuclear cells of recent-onset type 1 diabetes

AS Santos, E Cunha-Neto, NV Gonfinetti… - Frontiers in …, 2022 - frontiersin.org
Background Changes in innate and adaptive immunity occurring in/around pancreatic islets
had been observed in peripheral blood mononuclear cells (PBMC) of Caucasian T1D …

Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition

A Tomilov, S Allen, CK Hui, A Bettaieb… - Pharmacological …, 2018 - Elsevier
When insulin binds insulin receptor, IRS1 signaling is stimulated to trigger the maximal
insulin response. p52Shc protein competes directly with IRS1, thus damping and diverting …

Identification of common key genes and pathways between type 1 diabetes and multiple sclerosis using transcriptome and interactome analysis

N Safari-Alighiarloo, M Taghizadeh… - Endocrine, 2020 - Springer
Abstract Purpose Type 1 diabetes (T1D) and multiple sclerosis (MS) are classified as T cell-
mediated autoimmune diseases. Although convergent evidence proposed common genetic …

Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets

O Alcazar, M Ogihara, G Ren, P Buchwald… - Biomolecules, 2022 - mdpi.com
Background: Type 1 diabetes (T1D) is a devastating disease with serious health
complications. Early T1D biomarkers that could enable timely detection and prevention …

[HTML][HTML] A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information

R Karbalaei, M Piran, M Rezaei-Tavirani… - … and hepatology from …, 2017 - ncbi.nlm.nih.gov
Aim: Analysis reconstruction networks from two diseases, IBD and NASH and their
relationship, based on systems biology methods. Background: IBD and NASH are two …