Addiction is a chronic relapsing disorder with devastating personal, societal, and economic
consequences. In humans, early‐life adversity (ELA) such as trauma, neglect, and resource …

There is a high co-occurrence of risky substance use among adults with traumatic brain
injury (TBI), although it is unknown if the neurologic sequelae of TBI can promote this …

Drugs of abuse induce persistent remodeling of reward circuit function, a process thought to
underlie the emergence of drug craving and relapse to drug use. However, how circuit …

Ventral tegmental area (VTA) dopamine (DA) neurons perform diverse functions in
motivation and cognition, but their precise roles in addiction-related behaviors are still …

Background Comorbidity of anxiety disorders, stressor-and trauma-related disorders, and
substance use disorders is extremely common. Moreover, therapies that reduce pathological …

Addiction is a chronic relapsing disorder, and during recovery many people experience
several relapse events as they attempt to voluntarily abstain from drug. New preclinical …

Despite extensive research efforts, drug addiction persists as a largely unmet medical need.
Perhaps the biggest challenge for treating addiction is the high rate of recidivism. While …

The obesity epidemic is a leading cause of health problems in the United States, increasing
the risk of cardiovascular, endocrine, and psychiatric diseases. Although many people lose …

Despite its being historically conceptualized as a motor expression site, emerging evidence
suggests the ventral pallidum (VP) plays a more active role in integrating information to …

Here, we use optogenetics and chemogenetics to investigate the contribution of the
paraventricular thalamus (PVT) to nucleus accumbens (NAc) pathway in aversion and …