Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …

Cancer is a leading cause of death worldwide and there are still limited options for cure.
Chemotherapy is the most significant treatment for cancer which increased survival rates …

Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are
associated with cancer initiation, growth, and response to therapies. As concentrations …

Phenothiazines are molecules with great practical potential which have not yet been fully
explored. This review summarizes recent progress in the synthesis of 3, 7-disubstituted …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

In this review, we summarized the current literature on the impact of phenothiazine
derivatives on autophagy in vitro. Phenothiazines are antipsychotic drugs used in the …

Introduction The coronavirus disease 2019 (COVID-19), emerged in late 2019, was caused
by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The risk factors for …

Phenothiazines (PTZs) are a group of compounds characterized by the presence of the 10H-
dibenzo-[b, e]-1, 4-thiazine system. PTZs used in clinics as antipsychotic drugs with other …

Drug repurposing is a strategy that can speed up and find novel clinical uses for already-
approved drugs for several diseases, such as cancer. This process is accelerated compared …

The current review focuses on the effect of phenothiazine derivatives, tested in vitro, on
necrosis and necroptosis, the latter constitutes one of the kinds of programmed cell death …