Hypoxia, or lack of oxygen, can occur in both physiological (high altitude) and pathological
conditions (respiratory diseases). In this narrative review, we introduce high altitude …

Abstract Sphingosine 1-phosphate (S1P) is an important immune modulator responsible for
physiological cellular responses like lymphocyte development and function, positioning and …

We have studied the prophylactic efficacy of curcumin to ameliorate the impairment of tight
junction protein integrity and fluid clearance in lungs of rats under hypoxia. A549 cells …

Human carbonic anhydrase II (HCA II) uses a Zn-bound OH−/H2O mechanism to catalyze
the reversible hydration of CO2. This catalysis also involves a separate proton transfer step …

Abstract Sphingosine-1-phosphate (S1P) is emerging as a hypoxia responsive bio-lipid;
systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning …

High-altitude pulmonary edema (HAPE) is a potentially fatal condition, occurring at altitudes
greater than 3,000 m and affecting rapidly ascending, non-acclimatized healthy individuals …

It is well-known that in ischemia-induced hypoxia, hypoxia-inducible factor-1α (HIF-1α) is
critical in triggering expression of its downstream target genes to produce several products …

Systemic hypobaric hypoxia is reported to cause renal damage; nevertheless the exact
pathophysiological mechanisms are not completely understood. Therefore, the present …

High altitude pulmonary edema (HAPE) is generally characterized by the loss of alveolar
epithelial barrier integrity. The current study was undertaken to assess the noninvasive …

Abstract Sphingosine‐1‐phosphate (S1P) is emerging to have hypoxic preconditioning
potential in various preclinical studies. The study aims to evaluate the preclinical …