The genetic mutations that contribute to the transformation of healthy cells into cancerous
cells have been the subject of extensive research. The molecular aberrations that lead to …

The growing use of neoadjuvant chemotherapy to treat advanced stage high-grade serous
ovarian cancer (HGSOC) creates an opportunity to better understand chemotherapy …

Purpose: We sought to determine whether sequencing analysis of circulating cell-free DNA
(cfDNA) in patients with prospectively accrued endometrial cancer captures the mutational …

Purpose: Carcinomas originate from epithelial tissues, which have apical (luminal) and
basal orientations. The degree of luminal versus basal differentiation in cancer has been …

Basal breast cancer is associated with younger age, early relapse, and a high mortality rate.
Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate …

Metastasis accounts for poor prognosis of cancers and related deaths. Accumulating
evidence has shown that long noncoding RNAs (lncRNAs) play critical roles in several types …

Estrogen signaling through estrogen receptor alpha (ER) plays a major role in endometrial
cancer risk and progression, however, the molecular mechanisms underlying ER's …

Purpose Colorectal cancer (CRC) is one of the most common malignant tumors worldwide.
This study aimed to explore the prognostic value of lncRNAs in CRC. Material and methods …

Abstract Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds
many of the proteins essential for cancer development. CCT is expressed in diverse cancers …

Background Distinct prevalence of inherited genetic predisposition may partially explain the
difference of cancer risks across ancestries. Ancestry-specific analyses of germline …