Introduction: Selective serotonin and norepinephrine reuptake inhibitors (SNRI) are among
the most prescribed antidepressants, and dose escalation is a frequently applied strategy …

Objective The goal of this meta-analysis was to quantify the risk of dry mouth associated with
commonly prescribed antidepressant agents and examine the potential implications of …

Major depressive disorder (MDD) and other mental health issues pose a substantial burden
on the workforce. Approximately half a million Canadians will not be at work in any week …

Background The bidirectional association between Major Depressive Disorder (MDD) and
obesity suggests that body mass index (BMI) at the baseline could influence remission rates …

Importance Antidepressants are commonly used worldwide to treat major depressive
disorder. Symptomatic response to antidepressants can vary depending on differences …

Objectives: To evaluate the short-term efficacy and safety of desvenlafaxine (25–50 mg/d)
compared with placebo in children and adolescents with major depressive disorder (MDD) …

Background In an effort to establish the lowest effective dose of desvenlafaxine
(administered as desvenlafaxine succinate), we assessed the efficacy, safety, and …

This randomized, open label, prospective, observational study compared clinical efficacy,
safety alongwith plasma BDNF levels in outpatients of depression treated with fluoxetine …

Objective: To evaluate the short-term efficacy and safety of desvenlafaxine versus placebo in
the treatment of children and adolescents with major depressive disorder (MDD). Methods …

Background Desvenlafaxine and duloxetine are selective serotonin and norepinephrine
reuptake inhibitors. Their efficacy has not been directly compared using statistical …