An imbalance between excitation and inhibition has been a longstanding proposed
mechanism regarding ictogenesis and epileptogenesis. This imbalance is related to …

Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

Abstract Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …

Aging is characterized by a gradual decline of the body's biological functions, which can
lead to increased production of reactive oxygen species (ROS). Antioxidants neutralize ROS …

Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Objective: Studies have shown that oxidative stress (OS) is related to the pathophysiology of
schizophrenia (SCZ), but whether antipsychotics can induce OS has not been investigated …

Major depressive disorder (MDD) is highly prevalent and associated with considerable
morbidity, yet its pathophysiology remains only partially understood. While numerous …

The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major
depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic …

Purpose To test the efficacy of 7T MRS for in vivo detection of 2‐hydroxyglutarate (2HG) in
brain tumors. Methods The subecho times of point‐resolved spectroscopy (PRESS) were …