KRAS is the most commonly mutated oncogene in NSCLC and development of direct KRAS
inhibitors has renewed interest in this molecular variant. Different KRAS mutations may …

Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Purpose: Preoperative chemoradiotherapy (CRT) and surgical resection are the standard
treatment for locally advanced rectal cancer (LARC). Combining immune checkpoint …

Oncolytic virus (OV) therapy is now something of a misnomer. The initial paradigm was that
naturally occurring or genetically engineered viruses would preferentially infect, replicate in …

Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …

Great advances in immune checkpoint blockade have resulted in a paradigm shift in patients
with lung cancer. Immune-checkpoint inhibitor (ICI) treatment, either as monotherapy or …

Cancer is one of the main public health problems in the world. Systemic therapies such as
chemotherapy and more recently target therapies as well as immunotherapy have improved …

Squamous cell lung cancers (lung squamous cell carcinomas [LUSCs]) are associated with
high mortality and a lack of therapies specific to this disease. Although recurrent molecular …

Background: Radiotherapy-associated cardiac toxicity studies in patients with locally
advanced non–small cell lung cancer (NSCLC) have been limited by small sample size and …

Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …