Abstract Anti-PD-1/PD-L1 inhibitors provide a survival advantage over conventional
therapies for treatment of advanced or metastatic cancer. However, the factors determining …

Importance Unresected locally advanced non–small cell lung cancer (LA-NSCLC) shows
poor survival outcomes even after aggressive concurrent chemoradiotherapy. Whether …

Importance Sex-associated differences in immune response are known, but a meta-analysis
suggested men, compared with women, derive greater value from immunotherapy for …

RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

Significant technological advances in radiotherapy have been made in the past few
decades. High-precision radiotherapy has recently become popular and is contributing to …

The treatment of lung cancer has changed drastically in recent years owing to the advent of
immune checkpoint inhibitors (ICIs). A 1992 study reported that programmed cell death-1 …

Background Several accomplishments have been achieved in triple-negative breast cancer
(TNBC) research over the last year. The phase III IMpassion130 trial comparing …

The identification of inhibitory NK cell receptors specific for HLA-I molecules (KIRs and
NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill …

Background Immune checkpoint inhibitors (ICI) either alone or in combination with
chemotherapy have expanded our choice of agents for the palliative treatment of non-small …

Importance Non–small cell lung cancer (NSCLC) has relatively poor outcomes. Metformin
has significant data supporting its use as an antineoplastic agent. Objective To compare …