Heparin is well known for its anticoagulant and anti-inflammatory properties. Inhaled heparin
regimens are increasingly being used to manage lung disease. It has been used to treat …

Idiopathic pulmonary fibrosis (IPF) represents a particularly aggressive disease, the
aetiology of which still remains unknown. The natural history of the disease often leads to …

Background As a group, fibroproliferative disorders of the lung, liver, kidney, heart,
vasculature and integument are common, progressive and refractory to therapy. They can …

SUMMARY 1 Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a
component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic …

目前, 国内外关于特发性肺纤维化的研究报道较多, 但其发病机制尚不明确, 其治疗仍是临床一大
难题. IPF 发病分为肺间质炎症改变及随后的肺纤维化两个阶段, 很多细胞因子参与其中. IPF …

Idiopathic pulmonary fibrosis is a chronic, progressive and often fatal form of interstitial lung
disease. It is characterized by injury with loss of lung epithelial cells and abnormal tissue …

Th17 细胞是近年来新发现的一种能够分泌IL-l7 的效应T 细胞亚群, 是一群重要的介导炎症反应
的细胞. 关于肺纤维化形成机理的研究, 其具体的发病机制并不清楚, 近年来Th17 …

Macrophages and eosinophils that infiltrate the lung interstitium are active promoters of
bleomycin (BLM)-induced pulmonary fibrosis. Leukocyte infiltration indicates disrupted …

目的: 研究干扰素γ (IFN-γ) 抑制白细胞介素13 (IL-13) 对成纤维细胞纤维化作用的影响. 方法:
将成纤维细胞分为实验组和空白对照组, 实验组加入IFN-γ (4× 10^ 5U/L) 和IL-13 (100μg/L) …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with an average life expectancy
from diagnosis of 2.5 years with 5 year survival of between 20% and 40%. Currently there …