Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

Prurigo nodularis (PN) is a chronic inflammatory skin disease with intensely pruritic nodules.
The LIBERTY-PN PRIME and PRIME2 phase 3 trials enrolled adults with PN with≥ 20 …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …

Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …

Atopic dermatitis (AD) is a chronic skin disease caused by skin immune dyshomeostasis and
accompanied by severe pruritus. Although oxidative stress and mechanical scratching can …

Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic.
Pruritus might have a tremendous impact on patients' quality of life and strongly interfere …