A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability
that have been mainly characterized in the central nervous system. By contrast, there is a …

Previous studies in several different trigeminal nerve injury/inflammation models indicated
that the hyperexcitability of primary afferent neurons contributes to the pain pathway …

Nerve growth factor (NGF) modulates sensitivity and sprouting of nociceptors. We explored
the spatial and temporal sensitization induced by NGF injection (1 μg) in human skin …

Carefully orchestrated opening and closing of ion channels control the diffusion of ions
across cell membranes, generating the electrical signals required for fast transmission of …

It has been known for some time that the somata of neurons in sensory ganglia respond to
electrical or chemical stimulation and release transmitters in a Ca2+-dependent manner …

Cone snails produce a distinctive repertoire of venom peptides that are used both as a
defense mechanism and also to facilitate the immobilization and digestion of prey. These …

Osteoarthritis (OA) is a currently incurable, chronic, progressive, and debilitating
musculoskeletal (MSK) condition. One of its hallmark symptoms is chronic nociceptive and …

Bone cancer induced dynamic changes of A-type K+ channels in dorsal root ganglion
neurons. Diclofenac antagonized bone cancer pain by upregulating peripheral A-type K+ …

The glial cytokine, interleukin-1β (IL-1β), potentiates the excitability of nociceptive trigeminal
ganglion (TRG) neurons via membrane depolarization following peripheral inflammation …

Background Inappropriate matching of motor and sensory fibers after nerve repair or nerve
grafting can lead to failure of nerve recovery. Identification of motor and sensory fibers is …