High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair
JN Conroy, EJ Coulson - Journal of Biological Chemistry, 2022 - ASBMB
Neurotrophin signaling is essential for normal nervous system development and adult
function. Neurotrophins are secreted proteins that signal via interacting with two …
function. Neurotrophins are secreted proteins that signal via interacting with two …
The RTK interactome: overview and perspective on RTK heterointeractions
MD Paul, K Hristova - Chemical reviews, 2018 - ACS Publications
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution
The oligomeric organization of membrane proteins in native cell membranes is a critical
regulator of their function. High-resolution quantitative measurements of oligomeric …
regulator of their function. High-resolution quantitative measurements of oligomeric …
Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of …
Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …
The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity
MD Paul, K Hristova - Cytokine & growth factor reviews, 2019 - Elsevier
Here, we discuss the transition model of receptor tyrosine kinase (RTK) activation, which is
derived from biophysical investigations of RTK interactions and signaling. The model …
derived from biophysical investigations of RTK interactions and signaling. The model …
Quantifying the strength of heterointeractions among receptor tyrosine kinases from different subfamilies: Implications for cell signaling
MD Paul, HN Grubb, K Hristova - Journal of Biological Chemistry, 2020 - ASBMB
Receptor tyrosine kinases (RTKs) are single-pass membrane proteins that control vital cell
processes such as cell growth, survival, and differentiation. There is a growing body of …
processes such as cell growth, survival, and differentiation. There is a growing body of …
Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor
ML Franco, KD Nadezhdin, SA Goncharuk… - Journal of Biological …, 2020 - ASBMB
Tropomyosin-receptor kinases (TRKs) are essential for the development of the nervous
system. The molecular mechanism of TRKA activation by its ligand nerve growth factor …
system. The molecular mechanism of TRKA activation by its ligand nerve growth factor …
Pondering the mechanism of receptor tyrosine kinase activation: The case for ligand-specific dimer microstate ensembles
K Karl, K Hristova - Current opinion in structural biology, 2021 - Elsevier
Receptor tyrosine kinases (RTKs) are single-pass membrane proteins that regulate cell
growth, differentiation, motility, and metabolism. Here, we review recent advancements in …
growth, differentiation, motility, and metabolism. Here, we review recent advancements in …
Interaction between the transmembrane domains of neurotrophin receptors p75 and TrkA mediates their reciprocal activation
ML Franco, KD Nadezhdin, TP Light… - Journal of Biological …, 2021 - ASBMB
The neurotrophin receptors p75 and tyrosine protein kinase receptor A (TrkA) play important
roles in the development and survival of the nervous system. Biochemical data suggest that …
roles in the development and survival of the nervous system. Biochemical data suggest that …
A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain
TP Light, M Gomez-Soler, Z Wang, K Karl… - Journal of Biological …, 2021 - ASBMB
The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological and
pathological processes. EphA4 plays important roles in nervous system development and …
pathological processes. EphA4 plays important roles in nervous system development and …