Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …

Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …

The least damaging and most economical method to deliver drugs or carriers into the inner
ear for treatment of disease is through the middle ear. However, the retention of drug in the …

Hydrogel microrobots have blazed new avenues for local drug administration, while their
values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic …

Clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein
(CRISPR/Cas) system is an adaptable immune mechanism used by many bacteria to protect …

The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat
these conditions. Here, recent advances in drug delivery systems that access the ear …

Effective and safe treatment of auditory and vestibular diseases has become increasingly
dependent on inner ear drug delivery systems. This review highlights recent advances in …

Sensorineural hearing loss (SNHL) can be overcome by electrical stimulation of spiral
ganglion neurons (SGNs) via a cochlear implant (CI). Restricted CI performance results from …

Hearing loss caused by aging, noise, cisplatin toxicity, or other insults affects 360 million
people worldwide, but there are no Food and Drug Administration–approved drugs to …

Progress in drug delivery to the ear has been achieved over the last few years. This review
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …