The prevalence of autoimmune diseases has been increasing over the last 20 years. The
clinical presentation of this large and heterogeneous group of disorders depends on …

Cisplatin-induced hearing loss is a common side effect of cisplatin chemotherapy, for which
clinical therapy remains unavailable. Apoptosis of hair cells is considered the primary cause …

We prepared a new injectable thermogel to enhance the efficiency of inner ear delivery of
dexamethasone (DEX). Hexanoyl glycol chitosan (HGC) was synthesized and evaluated as …

Background Idiopathic sudden sensorineural hearing loss (ISSNHL) is common, and
defined as a sudden decrease in sensorineural hearing sensitivity of unknown aetiology …

Despite the high incidence of inner ear disorders, there are still no dedicated medications on
the market. Drugs are currently administered by the intratympanic route, the safest way to …

The properties of poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs) and penetration
enhancers play a deciding role in the inner ear drug delivery of NPs across the round …

The use of injectable hydrogel formulations for targeted drug delivery into the inner ear has
gained considerable interest. In this study, we introduce a novel self-degradable prodrug …

Microfabrication technology has enabled the development of novel controlled‐release
devices that possess an integration of structural, mechanical, and perhaps electronic …

Moderate noise exposure may cause acute loss of cochlear synapses without affecting the
cochlear hair cells and hearing threshold; thus, it remains" hidden" to standard clinical tests …

Local drug delivery systems have become an important field of research as locally
administration of medications may overcome most of the drawbacks associated with …