Exploitation of the host exocyst complex by bacterial pathogens

K Ireton, GC Gyanwali, TUB Herath… - Molecular …, 2023 - Wiley Online Library
Intracellular bacterial pathogens remodel the plasma membrane of eukaryotic cells in order
to establish infection. A common and well‐studied mechanism of plasma membrane …

[HTML][HTML] Regulation of phosphoinositide metabolism in Apicomplexan parasites

A Arabiotorre, VA Bankaitis, A Grabon - Frontiers in Cell and …, 2023 - frontiersin.org
Phosphoinositides are a biologically essential class of phospholipids that contribute to
organelle membrane identity, modulate membrane trafficking pathways, and are central …

[HTML][HTML] Picornavirus 3C Proteins Intervene in Host Cell Processes through Proteolysis and Interactions with RNA

S Mondal, G Sarvari, DD Boehr - Viruses, 2023 - mdpi.com
The Picornaviridae family comprises a large group of non-enveloped viruses with enormous
impact on human and animal health. The picornaviral genome contains one open reading …

[HTML][HTML] Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer

Y Jin, J Xue - Frontiers in Oncology, 2023 - frontiersin.org
Phosphoinositides, a small group of lipids found in all cellular membranes, have recently
garnered heightened attention due to their crucial roles in diverse biological processes and …

Ion-Induced PIP2 Clustering with Martini3: Modification of Phosphate–Ion Interactions and Comparison with CHARMM36

Z Jarin, RM Venable, K Han… - The Journal of Physical …, 2024 - ACS Publications
Phosphatidylinositol 4, 5-bisphosphate (PIP2) is a critical lipid for cellular signaling. The
specific phosphorylation of the inositol ring controls protein binding as well as clustering …

A new role for phosphoinositides in regulating mitochondrial dynamics

SR Lourdes, R Gurung, S Giri, CA Mitchell… - Advances in Biological …, 2023 - Elsevier
Phosphoinositides are a minor group of membrane-associated phospholipids that are
transiently generated on the cytoplasmic leaflet of many organelle membranes and the …

[HTML][HTML] A role for liquid-ordered plasma membrane nanodomains coordinating the unconventional secretory pathway of fibroblast growth factor 2?

F Lolicato, W Nickel - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that belongs to a subgroup of
extracellular proteins lacking N-terminal signal peptides. Whereas this phenomenon was …

Binding-induced lipid domains: Peptide-membrane interactions with PIP2 and PS

ZA Al-Mualem, X Chen, A Shafieenezhad… - Biophysical …, 2024 - cell.com
Cell signaling is an important process involving complex interactions between lipids and
proteins. The myristoylated alanine-rich C-kinase substrate (MARCKS) has been …

[HTML][HTML] The orchestrated signaling by PI3Kα and PTEN at the membrane interface

DM Kotzampasi, K Premeti, A Papafotika… - Computational and …, 2022 - Elsevier
The oncogene PI3Kα and the tumor suppressor PTEN represent two antagonistic enzymatic
activities that regulate the interconversion of the phosphoinositide lipids PI (4, 5) P 2 and PI …

[HTML][HTML] Actin-Membrane Linkers: Insights from Synthetic Reconstituted Systems

FC Tsai, G Guérin, J Pernier, P Bassereau - European Journal of Cell …, 2024 - Elsevier
At the cell surface, the actin cytoskeleton and the plasma membrane interact reciprocally in a
variety of processes related to the remodeling of the cell surface. The actin cytoskeleton has …