Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is
possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile …

Oncolytic adenoviruses (Ads) constitute a promising new class of anticancer agent. They are
based on the well-studied adenoviral vector system, which lends itself to concept-driven …

Herpes simplex virus type-1 (HSV1) in which the neurovirulence factor ICP34. 5 is
inactivated has been shown to direct tumour-specific cell lysis in several tumour models …

Purpose: Homozygous deletions at chromosome region 9p21 targeting the CDKN2A gene
have been reported as a common cytogenetic abnormality in mesothelioma. MTAP, a …

Purpose: ONYX-015 is a genetically modified adenovirus with a deletion of the E1B early
gene and is therefore designed to replicate preferentially in p53-mutated cells. A Phase II …

We have engineered a human adenovirus, ONYX-411, that selectively replicates in human
tumor cells, but not normal cells, depending upon the status of their retinoblastoma tumor …

Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and
destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is …

Context.—In recent decades, research on malignant pleural mesothelioma (MPM) has been
developed to improve patients' outcomes by increasing the level of confidence in MPM …

The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic
development. DNA damage promotes MDMX phosphorylation, nuclear translocation, and …

Oncolytic adenoviruses with restricted replication can be produced if the expression of
crucial transcription units of the virus is controlled by tissue-or tumor-specific promoters …