Mobile cognition: imaging the human brain in the 'real world'

M Stangl, SL Maoz, N Suthana - Nature Reviews Neuroscience, 2023 - nature.com
Cognitive neuroscience studies in humans have enabled decades of impactful discoveries
but have primarily been limited to recording the brain activity of immobile participants in a …

Spatial navigation deficits—overlooked cognitive marker for preclinical Alzheimer disease?

G Coughlan, J Laczó, J Hort, AM Minihane… - Nature Reviews …, 2018 - nature.com
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify
preclinical individuals and target potentially disease-modifying therapies towards them …

Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age

AD Ekstrom, PF Hill - Neuron, 2023 - cell.com
Spatial navigation and memory are often seen as heavily intertwined at the cognitive and
neural levels of analysis. We review models that hypothesize a central role for the medial …

Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience

Y Stern, CA Barnes, C Grady, RN Jones, N Raz - Neurobiology of aging, 2019 - Elsevier
Significant individual differences in the trajectories of cognitive aging and in age-related
changes of brain structure and function have been reported in the past half-century. In some …

Entropy of city street networks linked to future spatial navigation ability

A Coutrot, E Manley, S Goodroe, C Gahnstrom… - Nature, 2022 - nature.com
The cultural and geographical properties of the environment have been shown to deeply
influence cognition and mental health,,,,–. Living near green spaces has been found to be …

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

G Berdugo-Vega, G Arias-Gil… - Nature …, 2020 - nature.com
Functional plasticity of the brain decreases during ageing causing marked deficits in
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …

[PDF][PDF] Global determinants of navigation ability

A Coutrot, R Silva, E Manley, W de Cothi, S Sami… - Current Biology, 2018 - cell.com
Human spatial ability is modulated by a number of factors, including age [1–3] and gender
[4, 5]. Although a few studies showed that culture influences cognitive strategies [6–13], the …

Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer's disease

G Coughlan, A Coutrot, M Khondoker… - Proceedings of the …, 2019 - National Acad Sciences
Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer's
disease (AD). However, the impact of interindividual navigation ability and demographic risk …

Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation

D Howett, A Castegnaro, K Krzywicka, J Hagman… - Brain, 2019 - academic.oup.com
The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …

Consensus paper: Cerebellum and ageing

A Arleo, M Bareš, JA Bernard, HR Bogoian… - The Cerebellum, 2024 - Springer
Given the key roles of the cerebellum in motor, cognitive, and affective operations and given
the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the …