Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

Introduction Most drugs used in therapy have low water-solubility, a factor that could reduce
their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical …

Gut microbiota is known as unique collection of microorganisms (including bacteria,
archaea, eukaryotes and viruses) that exist in a complex environment of the gut. Recently …

A range of enteric polymers is used in pharmaceutical industry for developing gastro-
resistant formulations. It is generally implied that these coatings are interchangeable due to …

The rate and extent of drug dissolution in the gastrointestinal (GI) tract are highly dependent
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …

Recently, coamorphous systems, composed of a drug and a guest molecule, have gained
increasing interest, due to their ability to overcome limitations associated with amorphous …

Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical
Classification System (BCS) because of its poor aqueous solubility. In this study, we …

Being a biopharmaceutics classification system class II drug, the absorption of sertraline
from the gut is mainly limited by its poor aqueous solubility. The objective of this …

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …

The objective of this study was to formulate aripiprazole (ARI)-loaded pH-modulated solid
dispersions (SD) to enhance solubility, dissolution, and bioavailability via hot-melt extrusion …