Abstract 'They come in all sizes.'Apart from its origin and use in the clothing industry, this
saying reflects the fact that the size of organisms spans an enormous range. Whether …

The IGF system components have been implicated in breast cancer progression. IGF-I and
IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell …

It is well established that mitogens inhibit differentiation of skeletal muscle cells, but the
insulin-like growth factors (IGFs), acting through a single receptor, stimulate both …

Overexpression and activation of receptor tyrosine kinases, such as platelet derived growth
factor receptors (PDGFRs) and epidermal growth factor receptor (EGFR), leads to …

The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of
She complexed to a phosphopeptide reveals an alternative means of recognizing tryosine …

Peripheral neuropathy afflicts 60% of all diabetic patients. Underlying the clinical disorder is
the loss or degeneration of neurons, Schwann cells, and neuronal fibers. This degenerative …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive decline.
Despite worldwide efforts to find a cure, no proper treatment has been developed yet, and …

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the host
following an acute infection. Reactivation from latency contributes to the development of …

Ischemia/reperfusion (I/R) injury induces both functional and morphological changes in the
kidney. Necrosis, predominantly of the proximal tubule (PT), is the hallmark of this model of …

The Shc proteins have been implicated in the Ras signaling pathway by virtue of their
association with the Grb2 adaptor molecule. Several lines of evidence indicate that this …