Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

There has been rapid growth in the use of Drosophila and other invertebrate systems to
dissect mechanisms governing metabolism. New assays and approaches to physiology …

The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key
aspect of postnatal beta cell function. However, terminally differentiated beta cell identity …

Gene targeting studies in primary human islets could advance our understanding of
mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

Interactions between lineage-determining and activity-dependent transcription factors
determine single-cell identity and function within multicellular tissues through incompletely …

Glucose homeostasis depends on regulated insulin secretion from pancreatic β cells, which
acquire their mature phenotype postnatally. The functional maturation of β cells is regulated …