1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …

The National Cholesterol Education Program Adult Treatment Panel guidelines have
established low-density lipoprotein cholesterol (LDL-C) treatment goals, and secondary non …

Atherogenesis has been traditionally viewed as a metabolic disease representing arterial
obstruction by fatty deposits in its wall. Today, it is believed that atherogenesis involves …

Background Omega-3 fatty acids in free fatty acid form have enhanced bioavailability, and
plasma levels are less influenced by food than for ethyl ester forms. Objective The aim was …

Lysophosphatidylcholine (LPC) is a major plasma lipid that has been recognized as an
important cell signalling molecule produced under physiological conditions by the action of …

Despite recent advancements in the treatment of coronary artery disease (CAD), it remains
the number one cause of death in the world. While traditional risk factors partially account for …

A consensus panel was formed to review the rapidly emerging literature on the vascular-
specific inflammatory marker lipoprotein-associated phospholipase A2 (Lp-PLA2) and to …

The concepts of “cardiometabolic risk,”“metabolic syndrome,” and “risk stratification” overlap
and relate to the atherogenic process and development of type 2 diabetes. There is …

Inflammation and oxidative stress conditions lead to a variety of oxidative modifications of
lipoprotein phospholipids implicated in the occurrence and development of atherosclerotic …