The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive
subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide …

Recurrent somatic mutations in histone 3 (H3) variants (termed 'oncohistones') have been
identified in high-grade gliomas (HGGs) in children and young adults and induce …

Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by
clonal mutations in histone genes. They often harbor a range of additional genetic …

Pediatric cancers are rare diseases, and children without known germline predisposing
conditions who develop a second malignancy during developmental ages are extremely …

Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive
molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the …

PURPOSE Histone 3 (H3) K27M–mutant diffuse midline glioma (DMG) has a dismal
prognosis with no established effective therapy beyond radiation. This integrated analysis …

H3 K27‐altered diffuse midline glioma is a highly lethal pediatric‐type tumor without
efficacious treatments. Recent findings have highlighted the heterogeneity among diffuse …

Genomic rearrangements are a hallmark of most childhood tumors, including
medulloblastoma, one of the most common brain tumors in children, but their causes remain …

Identification of mutations in histones in a number of human neoplasms and developmental
syndromes represents the most compelling evidence to date for a causal role of epigenetic …