Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

[HTML][HTML] Essential metals in health and disease

K Jomova, M Makova, SY Alomar, SH Alwasel… - Chemico-biological …, 2022 - Elsevier
In total, twenty elements appear to be essential for the correct functioning of the human
body, half of which are metals and half are non-metals. Among those metals that are …

Oxidative stress and antioxidants in neurodegenerative disorders

EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

C Lennicke, HM Cochemé - Molecular Cell, 2021 - cell.com
Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

[HTML][HTML] The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease

B Brakedal, C Dölle, F Riemer, Y Ma, GS Nido… - Cell metabolism, 2022 - cell.com
We conducted a double-blinded phase I clinical trial to establish whether nicotinamide
adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside …

Redox regulation of immunometabolism

J Muri, M Kopf - Nature Reviews Immunology, 2021 - nature.com
Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Role of oxidative stress in depression

S Bhatt, AN Nagappa, CR Patil - Drug discovery today, 2020 - Elsevier
Highlights•The Reactive Oxygen Species have an utmost importance in progression of
Depression.•Depression is associated with lowered concentration of anti-oxidants in …

Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases

F Collin - International journal of molecular sciences, 2019 - mdpi.com
Increasing numbers of individuals suffer from neurodegenerative diseases, which are
characterized by progressive loss of neurons. Oxidative stress, in particular, the …

ROS-scavenging therapeutic hydrogels for modulation of the inflammatory response

YE Kim, J Kim - ACS Applied Materials & Interfaces, 2021 - ACS Publications
Although reactive oxygen species (ROS) are essential for cellular processes, excessive
ROS could be a major cause of various inflammatory diseases because of the oxidation of …