A review on the pharmacokinetic properties of naringin and its therapeutic efficacies in respiratory diseases

X Zeng, W Su, B Liu, L Chai, R Shi… - Mini Reviews in …, 2020 - ingentaconnect.com
Flavonoids are an important class of phytopharmaceuticals in plants. Naringin (naringenin-7-
O-rhamnoglucoside) is a flavanone glycoside isolated from folk herbal medicine Exocarpium …

Pharmacokinetics and metabolism of naringin and active metabolite naringenin in rats, dogs, humans, and the differences between species

Y Bai, W Peng, C Yang, W Zou, M Liu, H Wu… - Frontiers in …, 2020 - frontiersin.org
Background Pharmacokinetics provides a scientific basis for drug product design, dosage
regimen planning, understanding the body's action on the drug, and relating the time course …

Pharmacokinetics, tissue distribution, metabolism, and excretion of naringin in aged rats

X Zeng, W Su, Y Zheng, Y He, Y He, H Rao… - Frontiers in …, 2019 - frontiersin.org
Aging is an inevitable biological process characterized by the loss of functional capacity and
associated with changes in all phases of pharmacokinetic processes. Naringin, a dietary …

Microbial metabolism of naringin and the impact on antioxidant capacity

X Zeng, Y Zheng, Y He, J Zhang, W Peng, W Su - Nutrients, 2022 - mdpi.com
Naringin is a dietary flavonoid glycoside with broad bioactivities, and it has been found to
undergo extensive microbial metabolism in human gut. Microbial metabolites are believed to …

LC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme

NM Abd-El-Aziz, MS Hifnawy, RA Lotfy, IY Younis - Scientific Reports, 2024 - nature.com
Leontodon hispidulus Boiss is a wild annual plant growing in Egypt. The present study aims
for the first time, to evaluate the phytochemical profile of the main secondary metabolites of …

Characterization, in vitro and in vivo evaluation of naringenin-hydroxypropyl-β-cyclodextrin inclusion for pulmonary delivery

M Guan, R Shi, Y Zheng, X Zeng, W Fan, Y Wang… - Molecules, 2020 - mdpi.com
Naringenin, a flavonoid compound which exists abundantly in Citrus fruits, is proven to
possess excellent antitussive and expectorant effects. However, the clinical applications of …

Metabolite profiling of naringin in rat urine and feces using stable isotope-labeling-based liquid chromatography-mass spectrometry

X Zeng, H Yao, Y Zheng, T Chen, W Peng… - Journal of agricultural …, 2019 - ACS Publications
Naringin has been documented to possess various bioactivities. Due to thorny endogenous
interferences, the metabolism pathways of naringin and exact amounts of derived phenolic …

Modern Methods and Current Trends in the Analytical Chemistry of Flavanones

EN Yakupova, GK Ziyatdinova - Journal of Analytical Chemistry, 2023 - Springer
The review covers the specific features of the structure of flavanones and a critical review of
methods for their determination in various samples. The data are summarizes according to …

The selective electrochemical sensing of naringin using electropolymerized ellagic acid film

G Ziyatdinova, E Yakupova, E Guss… - Journal of the …, 2020 - iopscience.iop.org
Electrochemical sensor on the basis of glassy carbon electrode (GCE) covered with multi-
walled carbon nanotubes and electropolymerized ellagic acid (polyEA/MWNT/GCE) has …

Strategy to Improve the Oral Pharmacokinetics of Cyclin-Dependent Kinase 4/6 Inhibitors: Enhancing Permeability and CYP450 Inhibition by a Natural Bioenhancer

PH Patil, MP Desai, RR Rao, S Mutalik… - AAPS …, 2024 - Springer
Palbociclib and ribociclib an orally bioavailable, potent cyclin-dependent kinase 4/6
inhibitors, with low oral bioavailability due to substrate specificity towards CYP3A and P …