Effect of Span 20 Feeding Zone in the Twin Screw Extruder on the Properties of Amorphous Solid Dispersion of Ritonavir
H Wu, Z Wang, Y Zhao, Y Gao, H Zhang, L Wang… - Pharmaceutics, 2023 - mdpi.com
A ternary amorphous solid dispersion (ASD) system consisting of drug/polymer/surfactant is
receiving increased attention to improve the oral bioavailability of poorly water-soluble …
receiving increased attention to improve the oral bioavailability of poorly water-soluble …
Development and in vitro evaluation of gel formulation of atorvastatin solid dispersions
Atorvastatin is a statin group HMG-CoA reductase inhibitor drug that is commonly used to
adverse cardiovascular events and to lower blood total cholesterol and LDL-cholesterol. In …
adverse cardiovascular events and to lower blood total cholesterol and LDL-cholesterol. In …
[HTML][HTML] Facile fabrication of microparticles with pH-responsive macropores for small intestine targeted drug formulation
Oral drugs present the most convenient, economical, and painless route for self-
administration. Despite commercialization of multiple technologies relying on micro-and …
administration. Despite commercialization of multiple technologies relying on micro-and …
Approaches to understanding the solution-state organization of spray-dried dispersion feed solutions and its translation to the solid state
MK Defrese, MA Farmer, Y Long… - Molecular …, 2020 - ACS Publications
It is well established that polymers adopt a range of conformations and solution-state
organization in response to varying solution environments, although very little work has …
organization in response to varying solution environments, although very little work has …
Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles
K Mireskandari, M Rostamnezhad, M Darabi… - Pharmaceutical …, 2024 - ps.tbzmed.ac.ir
Background: Administering Cinacalcet HCl (CINA) can be challenging because of its low
oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor …
oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor …
[HTML][HTML] Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts
H Cheng, C Lu, G Xu, L Zhao, M Lu, Y Wang - Aaps Pharmscitech, 2022 - Springer
To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking
effects of different excipients were compared. Hydroxypropyl methylcellulose (HPMC)-VLV …
effects of different excipients were compared. Hydroxypropyl methylcellulose (HPMC)-VLV …
Upscaling and GMP production of pharmaceutical drug delivery systems
NG Türeli, AE Türeli - Drug Delivery Trends, 2020 - Elsevier
Thanks to the recent developments in nanotechnology, there have been great advances in
the field of nanomedicine. Development of nanotherapeutics and related therapies based on …
the field of nanomedicine. Development of nanotherapeutics and related therapies based on …
Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matrices
C Mazzoni, F Tentor, A Antalaki… - ACS Biomaterials …, 2019 - ACS Publications
To enhance oral bioavailability of poorly soluble drugs, microfabricated devices can be
utilized. One example of such devices is microcontainers. These are cylindrical in shape …
utilized. One example of such devices is microcontainers. These are cylindrical in shape …
Optimization of the drying process of standardized extracts from leaves of Spondias mombin L. using Box–Behnken design and response surface methodology
JCB Machado, MRA Ferreira… - Journal of Food …, 2021 - Wiley Online Library
The extracts of Spondias mombin leaves were obtained to study the influence of drug
amount and ethanol proportion on extract performance. The optimized extract was dried by …
amount and ethanol proportion on extract performance. The optimized extract was dried by …
The preparation of felodipine/zein amorphous solid dispersions and in vitro evaluation using a dynamic gastrointestinal system
Felodipine has been widely used as a poorly water-soluble model drug for various studies to
improve its oral bioavailability and in vivo efficacy. In this study, we developed amorphous …
improve its oral bioavailability and in vivo efficacy. In this study, we developed amorphous …