Type 2 diabetes
Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes
worldwide. The number affected is increasing rapidly with alarming trends in children and …
worldwide. The number affected is increasing rapidly with alarming trends in children and …
[HTML][HTML] Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
[HTML][HTML] Lipogenesis inhibitors: therapeutic opportunities and challenges
B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease
Recompensation has gained increasing attention in the field of cirrhosis, particularly in
chronic liver disease with a definite aetiology. The current global prevalence of obesity and …
chronic liver disease with a definite aetiology. The current global prevalence of obesity and …
Association of bariatric surgery with major adverse liver and cardiovascular outcomes in patients with biopsy-proven nonalcoholic steatohepatitis
A Aminian, A Al-Kurd, R Wilson, J Bena, H Fayazzadeh… - Jama, 2021 - jamanetwork.com
Importance No therapy has been shown to reduce the risk of serious adverse outcomes in
patients with nonalcoholic steatohepatitis (NASH). Objective To investigate the long-term …
patients with nonalcoholic steatohepatitis (NASH). Objective To investigate the long-term …
The associations between modifiable risk factors and nonalcoholic fatty liver disease: A comprehensive Mendelian randomization study
J Xie, H Huang, Z Liu, Y Li, C Yu, L Xu, C Xu - Hepatology, 2023 - journals.lww.com
Conclusions: Genetically predicted alcohol frequency, elevated serum liver enzymes, poor
physical condition, obesity traits, T2DM, and hypertension were associated with an …
physical condition, obesity traits, T2DM, and hypertension were associated with an …
Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease
JM Yabut, DJ Drucker - Endocrine Reviews, 2023 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …
Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …
[HTML][HTML] En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Genotype-phenotype associations for common diseases are often compounded by
pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of …
pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of …
[HTML][HTML] The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease
K Sawada, H Chung, S Softic, ME Moreno-Fernandez… - Cell Metabolism, 2023 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
for end-stage liver diseases with no available therapies. Dysregulated immune responses …