Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics

H Chen, C Chen, M Spanos, G Li, R Lu, Y Bei… - … and Targeted Therapy, 2022 - nature.com
Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Insight into the role of the PI3K/Akt pathway in ischemic injury and post-infarct left ventricular remodeling in normal and diabetic heart

B Walkowski, M Kleibert, M Majka, M Wojciechowska - Cells, 2022 - mdpi.com
Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …

Exercise training enhances myocardial mitophagy and improves cardiac function via Irisin/FNDC5-PINK1/Parkin pathway in MI mice

H Li, S Qin, Q Liang, Y Xi, W Bo, M Cai, Z Tian - Biomedicines, 2021 - mdpi.com
Myocardial infarction is the major cause of death in cardiovascular disease. In vitro and in
vivo models are used to find the exercise mode which has the most significant effect on …

MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training

AC Improta-Caria, LF Rodrigues… - American Journal …, 2024 - journals.physiology.org
Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity
develop long-term fibrotic processes in the heart, promoting pathological cardiac …

Human platelet lysate‐derived extracellular vesicles enhance angiogenesis through miR‐126

A Bordin, M Chirivì, F Pagano, M Milan… - Cell …, 2022 - Wiley Online Library
Abstract Objectives Extracellular vesicles (EVs) are key biological mediators of several
physiological functions within the cell microenvironment. Platelets are the most abundant …

Therapeutic potentials of microRNA-126 in cerebral ischemia

V Ebrahimi, SH Rastegar-Moghaddam… - Molecular …, 2023 - Springer
Stroke is a leading cause of death and disability worldwide. It is among the most common
neurological disorders with an 8–10% lifetime risk. Ischemic stroke accounts for about 85 …

Interaction of exercise training with taurine attenuates infarct size and cardiac dysfunction via Akt–Foxo3a–Caspase-8 signaling pathway

A Razzaghi, S Choobineh, A Gaeini, R Soori - Amino Acids, 2023 - Springer
This research aimed to investigate the synergistic protective effect of exercise training and
taurine on Akt–Foxo3a–Caspase-8 signaling related to infarct size and cardiac dysfunction …

Molecular mechanisms of Neuroprotection after the intermittent exposures of Hypercapnic Hypoxia

PP Tregub, VP Kulikov, I Ibrahimli, OF Tregub… - International Journal of …, 2024 - mdpi.com
The review introduces the stages of formation and experimental confirmation of the
hypothesis regarding the mutual potentiation of neuroprotective effects of hypoxia and …

Conditioned medium derived from 3D tooth germs: A novel cocktail for stem cell priming and early in vivo pulp regeneration

T Zhou, M Rong, Z Wang, H Chu, C Chen… - Cell …, 2021 - Wiley Online Library
Objectives Conditioned medium (CM) from 2D cell culture can mitigate the weakened
regenerative capacity of the implanted stem cells. However, the capacity of 3D CM to prime …

Exosomes derived from stem cells from apical papilla promote angiogenesis via miR‐126 under hypoxia

X Lin, H Wang, T Wu, Y Zhu, L Jiang - Oral diseases, 2023 - Wiley Online Library
Objectives To explore the effect of exosomal miR‐126 derived from stem cells from the
apical papilla (SCAPs) under hypoxia on human umbilical vein endothelial cell (HUVEC) …