Transcriptional and epigenetic decoding of the microglial aging process
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders
Glutamate is the main excitatory neurotransmitter in the brain wherein it controls cognitive
functional domains and mood. Indeed, brain areas involved in memory formation and …
functional domains and mood. Indeed, brain areas involved in memory formation and …
[HTML][HTML] GABAB1 receptor knockdown in prefrontal cortex induces behavioral aberrations associated with autism spectrum disorder in mice
X Wang, Z Zhao, J Guo, D Mei, Y Duan, Y Zhang… - Brain Research …, 2023 - Elsevier
Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental disorders,
characterized by social interaction deficit, stereotyped or repetitive behaviors. Apart from …
characterized by social interaction deficit, stereotyped or repetitive behaviors. Apart from …
Associations between dysbiosis gut microbiota and changes of neurotransmitters and short-chain fatty acids in valproic acid model rats
JG Zhong, WT Lan, YQ Feng, YH Li, YY Shen… - Frontiers in …, 2023 - frontiersin.org
Introduction: The microbiota–gut–brain axis plays an important role in the pathophysiology
of autism spectrum disorder, but its specific mechanisms remain unclear. This study aimed to …
of autism spectrum disorder, but its specific mechanisms remain unclear. This study aimed to …
Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho …
AU Carbonell, C Freire-Cobo, IV Deyneko… - Frontiers in Aging …, 2023 - frontiersin.org
Specific and effective treatments for autism spectrum disorder (ASD) are lacking due to a
poor understanding of disease mechanisms. Here we test the idea that similarities between …
poor understanding of disease mechanisms. Here we test the idea that similarities between …
Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1−/− mice
J Wang, Y Gao, L Xiao, Y Lin, L Huang, J Chen… - Iscience, 2023 - cell.com
Mutations of the GABA-A receptor subunit β1 (GABRB1) gene are found in autism patients.
However, it remains unclear how mutations in Gabrb1 may lead to autism. We generated …
However, it remains unclear how mutations in Gabrb1 may lead to autism. We generated …
[HTML][HTML] FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex
A Falace, L Corbieres, C Palminha, FC Guarnieri… - Neurobiology of …, 2024 - Elsevier
Periventricular nodular heterotopia (PNH), the most common brain malformation diagnosed
in adulthood, is characterized by the presence of neuronal nodules along the ventricular …
in adulthood, is characterized by the presence of neuronal nodules along the ventricular …
[HTML][HTML] Challenges and prospects in the autism spectrum disorder field
The latest epidemiological survey has revealed that autism spectrum disorder (ASD) is one
of the significant population health issues, with an incidence rate of approximately 0.7 …
of the significant population health issues, with an incidence rate of approximately 0.7 …