Genes in which germline mutations confer highly or moderately increased risks of cancer
are called cancer predisposition genes. More than 100 of these genes have been identified …

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from the
parafollicular cells. The diagnostic and therapeutic strategies for the condition are different …

Background The early detection of medullary thyroid carcinoma (MTC) can improve patient
prognosis, because histological stage and patient age at diagnosis are highly relevant …

Purpose To retrospectively evaluate and compare 18 F-FDG, 18 F-DOPA and 68 Ga-
somatostatin analogues for PET/CT in patients with residual/recurrent medullary thyroid …

Abstract On April 6, 2011, the US Food and Drug Administration approved vandetanib
(Caprelsa tablets; AstraZeneca Pharmaceuticals LP) for the treatment of symptomatic or …

Purpose The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting
medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin …

Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter
norepinephrine and specifically targets neuroendocrine cells including some …

Current understanding infers a neural crest origin of thyroid C cells, the major source of
calcitonin in mammals and ancestors to neuroendocrine thyroid tumors. The concept is …

Introduction This study aimed to systematically elucidate the metastatic patterns and their
corresponding survival of each thyroid cancer subtype at time of diagnosis. Methods We …

Since its first description in 1951, a timely diagnosis of medullary thyroid carcinoma (MTC)
may represent a diagnostic challenge in clinical practice. Several contributions have been …