Pyrazolyl derivatives as Syk inhibitors

MR Machacek, MD Altman, ET Romeo… - US Patent …, 2016 - Google Patents
2015-10-21 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Substituted pyridine spleen tyrosine kinase (SYK) inhibitors

AM Haidle, SL Knowles, SD Kattar… - US Patent …, 2016 - Google Patents
2015-11-06 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Imidazolyl analogs as syk inhibitors

J Lim, MH Reutershan, JM Ellis, KK Childers… - US Patent …, 2016 - Google Patents
Int. Cl. C07D 403/12(2006.01) The present invention provides novel imidazole analogs of
C07D 403/14(2006.01) Formula I which are potent inhibitors of spleen tyrosine C07D …

Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors

AM Haidle, MD Altman, SD Kattar… - US Patent …, 2016 - Google Patents
The invention provides certain substituted diazine and triaz ine compounds of the Formula
(I)(I) or pharmaceutically acceptable salts thereof, wherein R', RRRRC, and t are as defined …

Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors

AM Haidle, J Burch, D Guay, JY Gauthier… - US Patent …, 2016 - Google Patents
The invention provides certain Substituted phenyl compounds of the Formula (I) or
pharmaceutically acceptable salts thereof, wherein R', RRRR, and t are as defined herein …

Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors

KL Arrington, B DuBois, JS Debenham, P Liu… - US Patent …, 2016 - Google Patents
9,006,444 B2 4/2015 Altman et al. WO 2007042298 A1 4, 2007 9,120,785 B2 9/2015 Altman
et al. WO 2007042.299 A1 4, 2007 9,145,391 B2 9/2015 Deschenes et al. WO 2007070872 …

Prodrug bipyridylaminopyridines as syk inhibitors

AM Haidle, B Cash, JP Jewell, K Spencer… - US Patent App. 14 …, 2015 - Google Patents
0001 Spleen Tyrosine Kinase (Syk) is a protein tyrosine kinase which has been described
as a key mediator of immu noreceptor signalling in a host of inflammatory cells includ ing …

Amino-pyrimidine-containing spleen tyrosine kinase (Syk) inhibitors

MR Machacek - US Patent 9,624,210, 2017 - Google Patents
The invention provides certain amino-pyrimidine-contain ing compounds. The invention also
provides pharmaceutical compositions comprising such compounds, and methods of using …

Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors

MR Machacek, ET Romeo, AB Northrup… - US Patent …, 2017 - Google Patents
The invention provides certain thiazole-substituted amino heteroaryl compounds of the
Formula (I) or pharmaceuti cally acceptable salts thereof, wherein R', R", RS, RC, A, Cy and …

Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors

TA Miller, A Petrocchi, ET Romeo, D Vitharana… - US Patent …, 2017 - Google Patents
US9670196B2 - Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase
inhibitors - Google Patents US9670196B2 - Thiazole-substituted aminoheteroaryls as …