Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly
understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan …

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic
syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in …

Aging research has been very successful at identifying signaling pathways and
evolutionarily conserved genes that extend lifespan with the assumption that an increase in …

Research into the molecular and developmental biology of the nematode Caenorhabditis
elegans was begun in the early seventies by Sydney Brenner and it has since been used …

To dampen proteotoxic stresses and maintain protein homeostasis, organisms possess a
stress-responsive molecular machinery that detects and neutralizes protein damage. A …

As human life expectancy is prolonged, age-related diseases are thriving. Aging is a
complex multifactorial process of molecular and cellular decline that affects tissue function …

Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …

Cancer is the second leading cause of death in the USA and among the leading major
diseases in the world. It is anticipated to continue to increase because of the growth of the …