Nonantimicrobial actions of macrolides: overview and perspectives for future development

JA Kricker, CP Page, FR Gardarsson… - Pharmacological …, 2021 - ASPET
Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly
for respiratory infections. It is now recognized that these drugs, in particular azithromycin …

Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma

P Kachroo, ID Stewart, RS Kelly, M Stav, K Mendez… - Nature medicine, 2022 - nature.com
The application of large-scale metabolomic profiling provides new opportunities for realizing
the potential of omics-based precision medicine for asthma. By leveraging data from over …

Treatable traits, combination inhaler therapy and the future of asthma management

PG Gibson, VM McDonald, D Thomas - Respirology, 2023 - Wiley Online Library
The landscape of asthma has considerably changed in the last decade. Effective
medications and inhaler devices have been developed and integrated into the asthma …

[HTML][HTML] Unraveling the Impact of Salbutamol Polytherapy: Clinically Relevant Drug Interactions

L Marques, N Vale - Future Pharmacology, 2023 - mdpi.com
The proper drug choice determines the treatment quality for a disease. The
pharmacotherapeutic strategy for respiratory diseases often involves the combination of …

Pharmacokinetic considerations surrounding triple therapy for uncontrolled asthma

MG Matera, B Rinaldi, C Belardo… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Solid pharmacological rationale and clinical evidence support the use of a
combination of an inhaled corticosteroid (ICS), a long-acting β2-agonist, and a long-acting …

[HTML][HTML] Transcriptome analysis in patients with asthma after inhaled combination therapy with long-acting β2-agonists and corticosteroids

YR Liang, IS Tzeng, PC Hsieh, CY Kuo… - … journal of medical …, 2022 - ncbi.nlm.nih.gov
Introduction: Asthma is one of the major public health problems that imposes a great burden
on societal, financial, and healthcare around the world. Asthma poorly affects the health …

[HTML][HTML] Interacciones farmacocinéticas de la azitromicina e implicación clínica

M Saravia Bartra, R Losno García… - Revista Cubana de …, 2021 - scielo.sld.cu
Objetivos: Revisar e integrar la información sobre las interacciones farmacocinéticas de la
azitromicina que se prescriben en el tratamiento ambulatorio de la COVID-19 en el Perú, y …

Inadequate therapeutic responses to glucocorticoid treatment in bronchial asthma

Y Matsumura - Journal of International Medical Research, 2023 - journals.sagepub.com
Bronchial asthma (BA) is a heterogeneous disease. Some patients benefit greatly from
glucocorticoid (GC) treatment, whereas others are non-responders. This could be …

Potential polymorphic CYP1A2 and CYP2D6-mediated pharmacokinetic interactions between risperidone or olanzapine and selected drugs intended to treat COVID …

A Rojas-Macetas, G Medalla-Garro… - Drug Metabolism …, 2023 - ingentaconnect.com
Risperidone/olanzapine are antipsychotics used in Peru to control symptoms of psychosis.
The objective was to review the available evidence on potential pharmacokinetic …

Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes

S Sahana, A Sivadas, M Mangla, A Jain… - …, 2021 - Future Medicine
Aim: Numerous drugs are being widely prescribed for COVID-19 treatment without any direct
evidence for the drug safety/efficacy in patients across diverse ethnic populations. Materials …