Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
Objective To systematically assess credibility and certainty of associations between
cannabis, cannabinoids, and cannabis based medicines and human health, from …
cannabis, cannabinoids, and cannabis based medicines and human health, from …
[HTML][HTML] Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway
M Tanaka, F Tóth, H Polyák, Á Szabó, Y Mándi… - Biomedicines, 2021 - mdpi.com
The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
[HTML][HTML] Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
Recreational cannabis legalization alters associations among cannabis use, perception of risk, and cannabis use disorder treatment for adolescents and young adults
J Mennis, TP McKeon, GJ Stahler - Addictive behaviors, 2023 - Elsevier
Objective Understanding how recreational cannabis legalization may impact cannabis use
disorder (CUD) among adolescents and young adults is key to developing an appropriate …
disorder (CUD) among adolescents and young adults is key to developing an appropriate …
[HTML][HTML] Therapeutic effect of psilocybin in addiction: A systematic review
PB van der Meer, JJ Fuentes, AA Kaptein… - Frontiers in …, 2023 - frontiersin.org
Background Psychedelic-assisted therapy [eg, with lysergic acid diethylamide (LSD)] has
shown promising results as treatment for substance use disorders (SUDs). Previous …
shown promising results as treatment for substance use disorders (SUDs). Previous …
Prevalence of adolescent cannabis vaping: a systematic review and meta-analysis of US and Canadian studies
Importance Vaping products were initially designed to deliver nicotine as a tobacco cigarette
substitute (eg, electronic cigarettes) but are now frequently used to deliver psychoactive …
substitute (eg, electronic cigarettes) but are now frequently used to deliver psychoactive …
[HTML][HTML] Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
M Haney, M Vallée, S Fabre, S Collins Reed… - Nature Medicine, 2023 - nature.com
Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate
its treatment. AEF0117, the first of a new pharmacological class, is a signaling-specific …
its treatment. AEF0117, the first of a new pharmacological class, is a signaling-specific …
[HTML][HTML] Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …
executive and emotional functions. Neurophysiological studies have begun to unveil the …
[HTML][HTML] Cannabis: a multifaceted plant with endless potentials
Cannabis sativa, also known as “hemp” or “weed,” is a versatile plant with various uses in
medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available …
medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available …
[HTML][HTML] Public health monitoring of cannabis use in Europe: prevalence of use, cannabis potency, and treatment rates
Background Cannabis is one of the most widely used substances worldwide. Heavy use is
associated with an increased risk of cannabis use disorders, psychotic disorders, acute …
associated with an increased risk of cannabis use disorders, psychotic disorders, acute …