Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
Regulated cell death pathways in kidney disease
AB Sanz, MD Sanchez-Niño, AM Ramos… - Nature Reviews …, 2023 - nature.com
Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …
Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration
The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …
[HTML][HTML] Capillary leak syndrome: etiologies, pathophysiology, and management
E Siddall, M Khatri, J Radhakrishnan - Kidney International, 2017 - Elsevier
In various human diseases, an increase in capillary permeability to proteins leads to the loss
of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the …
of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the …
[HTML][HTML] Pathophysiology of acute kidney injury
DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …
In Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia–Reperfusion Injury
H Cao, Y Cheng, H Gao, J Zhuang, W Zhang, Q Bian… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited
regenerative capability in animal models of ischemia–reperfusion (I/R) acute kidney injury …
regenerative capability in animal models of ischemia–reperfusion (I/R) acute kidney injury …
Cell death in the kidney
G Priante, L Gianesello, M Ceol, D Del Prete… - International journal of …, 2019 - mdpi.com
Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …
Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during
acute kidney injury, remains largely unknown. Here, we have demonstrated a striking …
acute kidney injury, remains largely unknown. Here, we have demonstrated a striking …
The role of PGC-1α and mitochondrial biogenesis in kidney diseases
M Fontecha-Barriuso, D Martin-Sanchez… - Biomolecules, 2020 - mdpi.com
Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide,
emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute …
emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute …
The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB
JA Moreno, MC Izquierdo… - Journal of the …, 2011 - journals.lww.com
Proinflammatory cytokines contribute to renal injury, but the downstream effectors within
kidney cells are not well understood. One candidate effector is Klotho, a protein expressed …
kidney cells are not well understood. One candidate effector is Klotho, a protein expressed …