Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

In various human diseases, an increase in capillary permeability to proteins leads to the loss
of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the …

Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited
regenerative capability in animal models of ischemia–reperfusion (I/R) acute kidney injury …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during
acute kidney injury, remains largely unknown. Here, we have demonstrated a striking …

Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide,
emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute …

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within
kidney cells are not well understood. One candidate effector is Klotho, a protein expressed …