Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

Introduction: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health
problem. There is currently an urgent and unmet need for the development of small …

Neutrophil activation after trauma–hemorrhagic shock (T/H) has been implicated in the
development of multiple organ dysfunction (MOD). In this study, we report that a small …

INTRODUCTION: The distribution of chronic obstructive pulmonary disease (COPD) in
women, and its underdiagnosis and determinants in the general population, have not been …

Introducción La distribución de la enfermedad pulmonar obstructiva crónica (EPOC) en
mujeres y su infradiagnóstico y determinantes en la población no están bien descritos. El …

Oxidative stress caused by neutrophils is an important pathogenic factor in
trauma/hemorrhagic (T/H)-induced acute lung injury (ALI). Osthol, a natural coumarin found …

Abstract Phosphodiesterase-4 inhibitors (PDE4) are of great interest for the treatment of
airway inflammatory diseases due to its broad anti-inflammatory effects. Roflumilast is a …

Background Oxidative stress is present in airway diseases such as severe asthma or
Chronic Obstructive Pulmonary Disease and contributes to the low response to …

Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are
currently used in the treatment of several chronic inflammatory disorders, including chronic …

Roflumilast is a selective once daily, oral phosphodiesterase-4 inhibitor that has recently
been registered in all European Union countries as novel targeted therapy for COPD, while …