Genome‐wide association studies for discovery of genes involved in asthma

L Akhabir, AJ Sandford - Respirology, 2011 - Wiley Online Library
Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

Neutrophil elastase inhibitors

WC Groutas, D Dou, KR Alliston - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health
problem. There is currently an urgent and unmet need for the development of small …

2-(2-Fluorobenzamido) benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ …

HP Yu, PW Hsieh, YJ Chang, PJ Chung, LM Kuo… - Free Radical Biology …, 2011 - Elsevier
Neutrophil activation after trauma–hemorrhagic shock (T/H) has been implicated in the
development of multiple organ dysfunction (MOD). In this study, we report that a small …

Underdiagnosis of chronic obstructive pulmonary disease in women: quantification of the problem, determinants and proposed actions

J Ancochea, M Miravitlles, F García-Río… - Archivos de …, 2013 - Elsevier
INTRODUCTION: The distribution of chronic obstructive pulmonary disease (COPD) in
women, and its underdiagnosis and determinants in the general population, have not been …

Infradiagnóstico de la enfermedad pulmonar obstructiva crónica en mujeres: cuantificación del problema, determinantes y propuestas de acción

J Ancochea, M Miravitlles, F García-Río… - Archivos de …, 2013 - Elsevier
Introducción La distribución de la enfermedad pulmonar obstructiva crónica (EPOC) en
mujeres y su infradiagnóstico y determinantes en la población no están bien descritos. El …

Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4

YF Tsai, HP Yu, PJ Chung, YL Leu, LM Kuo… - Free Radical Biology …, 2015 - Elsevier
Oxidative stress caused by neutrophils is an important pathogenic factor in
trauma/hemorrhagic (T/H)-induced acute lung injury (ALI). Osthol, a natural coumarin found …

Current insights on clinical efficacy of roflumilast for treatment of COPD, asthma and ACOS

S Bodkhe, M Nikam, AP Sherje, T Khan… - International …, 2020 - Elsevier
Abstract Phosphodiesterase-4 inhibitors (PDE4) are of great interest for the treatment of
airway inflammatory diseases due to its broad anti-inflammatory effects. Roflumilast is a …

Oxidative stress‐induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages

J Milara, A Navarro, P Almudever… - Clinical & …, 2011 - Wiley Online Library
Background Oxidative stress is present in airway diseases such as severe asthma or
Chronic Obstructive Pulmonary Disease and contributes to the low response to …

[HTML][HTML] Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung

A Oldenburger, H Maarsingh, M Schmidt - Pharmaceuticals, 2012 - mdpi.com
Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are
currently used in the treatment of several chronic inflammatory disorders, including chronic …

PDE4-inhibitors: a novel, targeted therapy for obstructive airways disease

Z Diamant, D Spina - Pulmonary pharmacology & therapeutics, 2011 - Elsevier
Roflumilast is a selective once daily, oral phosphodiesterase-4 inhibitor that has recently
been registered in all European Union countries as novel targeted therapy for COPD, while …