Overview of myelin, major myelin lipids, and myelin-associated proteins
A Kister, I Kister - Frontiers in Chemistry, 2023 - frontiersin.org
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …
Neuron-oligodendrocyte interactions in the structure and integrity of axons
The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health
ZJ Looser, Z Faik, L Ravotto, HS Zanker, RB Jung… - Nature …, 2024 - nature.com
The integrity of myelinated axons relies on homeostatic support from oligodendrocytes
(OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic …
(OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic …
Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles
EM Krämer-Albers, HB Werner - Nature Reviews Neuroscience, 2023 - nature.com
Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …
communication in the nervous system, mediating tissue homeostasis. EVs influence the …
[HTML][HTML] Insights into myelin dysfunction in schizophrenia and bipolar disorder
M Valdés-Tovar, AM Rodríguez-Ramírez… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide
prevalence of approximately 1%. Both disorders present chronic and deteriorating …
prevalence of approximately 1%. Both disorders present chronic and deteriorating …
Ensheathment and myelination of axons: evolution of glial functions
Myelination of axons provides the structural basis for rapid saltatory impulse propagation
along vertebrate fiber tracts, a well-established neurophysiological concept. However …
along vertebrate fiber tracts, a well-established neurophysiological concept. However …
Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice
VI Gargareta, J Reuschenbach, SB Siems, T Sun… - Elife, 2022 - elifesciences.org
Human myelin disorders are commonly studied in mouse models. Since both clades
evolutionarily diverged approximately 85 million years ago, it is critical to know to what …
evolutionarily diverged approximately 85 million years ago, it is critical to know to what …
White matter integrity in mice requires continuous myelin synthesis at the inner tongue
M Meschkat, AM Steyer, MT Weil, K Kusch… - Nature …, 2022 - nature.com
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time.
However, it is composed of proteins with long lifetimes. This raises the question how such a …
However, it is composed of proteins with long lifetimes. This raises the question how such a …
Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD)
activity have been observed in several neurodegenerative diseases. PC is a …
activity have been observed in several neurodegenerative diseases. PC is a …
Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system
Central nervous system (CNS) disorders and trauma involving changes to the neuronal
myelin sheath have long been a topic of great interest. One common pathological change in …
myelin sheath have long been a topic of great interest. One common pathological change in …