TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Antioxidative and anti-inflammatory properties of cannabidiol

S Atalay, I Jarocka-Karpowicz, E Skrzydlewska - Antioxidants, 2019 - mdpi.com
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …

A microbiome-dependent gut–brain pathway regulates motivation for exercise

L Dohnalová, P Lundgren, JRE Carty, N Goldstein… - Nature, 2022 - nature.com
Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …

The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages

SM Anil, N Shalev, AC Vinayaka, S Nadarajan… - Scientific reports, 2021 - nature.com
Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity. This
study intended to examine the anti-inflammatory activity of cannabis on immune response …

Cannabis Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain

G Crescente, G Minervini, C Spagnuolo, S Moccia - Molecules, 2022 - mdpi.com
The management of orofacial pain to alleviate the quality of life of affected patients is
becoming increasingly challenging for scientific research and healthcare professionals …

Targeting cannabinoid receptors: current status and prospects of natural products

D An, S Peigneur, LA Hendrickx, J Tytgat - International journal of …, 2020 - mdpi.com
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …

The polypharmacological effects of cannabidiol

J Castillo-Arellano, A Canseco-Alba, SJ Cutler, F León - Molecules, 2023 - mdpi.com
Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …

The pharmacological case for cannabigerol

R Nachnani, WM Raup-Konsavage, KE Vrana - Journal of Pharmacology …, 2021 - ASPET
Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC)
and cannabidiol (CBD), are receiving growing attention in both the media and the scientific …