Cancer biomarker detection: recent achievements and challenges
L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …
a great deal of effort has been devoted to the exploration of new technologies to detect early …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
Human telomerase and its regulation
YS Cong, WE Wright, JW Shay - Microbiology and molecular …, 2002 - Am Soc Microbiol
The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
[图书][B] Epigenetic mechanisms of gene regulation.
VEA Russo, RA Martienssen, AD Riggs - 1996 - cabidigitallibrary.org
This book comprehensively covers epigenetic mechanisms, including DNA methylation,
paramutation, imprinting, X-inactivation, repeated genes, gene silencing, nuclear …
paramutation, imprinting, X-inactivation, repeated genes, gene silencing, nuclear …
Alterations in DNA methylation: a fundamental aspect of neoplasia
Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
Epigenetic regulation in plant responses to the environment
DC Baulcombe, C Dean - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
In this article, we review environmentally mediated epigenetic regulation in plants using two
case histories. One of these, vernalization, mediates adaptation of plants to different …
case histories. One of these, vernalization, mediates adaptation of plants to different …
[HTML][HTML] DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium
during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism …
during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism …
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
L Zuo, J Weger, Q Yang, AM Goldstein, MA Tucker… - Nature …, 1996 - nature.com
Protein complexes consisting of a cyclin-dependent kinase (CDK4 or CDK6) and cyclin D
control passage through the G1 checkpoint of the cell cycle by phosphorylating the …
control passage through the G1 checkpoint of the cell cycle by phosphorylating the …
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.
R Jüttermann, E Li, R Jaenisch - Proceedings of the …, 1994 - National Acad Sciences
The deoxycytidine analog 5-aza-2'-deoxycytidine (5-azadCyd) has been widely used as a
DNA methylation inhibitor to experimentally induce gene expression and cellular …
DNA methylation inhibitor to experimentally induce gene expression and cellular …