It is hypothesized that diets deficient in folate, methionine, and vitamins B-6 and B-12 cause
DNA hypomethylation and, as a result, increase risk of colorectal cancers. Furthermore, it is …

Breast cancer is a genetic disease arising from a series of germ-line and/or somatic DNA
changes in a variety of genes, including BRCA1 and BRCA2. DNA modifications have been …

Reactive oxygen species can initiate carcinogenesis by virtue of their capacity to react with
DNA and cause mutations. Recently, it has been suggested that nitric oxide (NO) and its …

The immune response to pathogens is regulated by a delicate balance of cytokines. The
dysregulation of cytokine gene expression, including interleukin-12, tumor necrosis factor …

BACKGROUND AND AIMS: Diminished folate status is associated with enhanced colorectal
carcinogenesis. This study investigated the potential chemopreventive role of dietary folate …

Hypermethylation of exon 1 of p16 INK4a was examined in tumour and plasma DNA of a
series of breast cancer patients. De novo methylation was observed in the tumours of eight …

The study of human disease has been greatly facilitated by the use of animal model
systems. Recent advances in the understanding of the genetics and biology of the mouse …

The last decade has seen an incredible breakthrough in technologies that allow histones,
transcription factors (TFs), and RNA polymerases to be precisely mapped throughout the …

Cancer cells are characterized by a generalized disruption of the DNA methylation pattern
involving an overall decrease in the level of 5-methylcytosine together with regional …

It is well known that epithelial-mesenchymal transition (EMT) can confer cancer cells with
invasive and migratory capabilities associated with distant metastasis. As a key upstream …