Complexity‐to‐Diversity and Pseudo‐Natural Product Strategies as Powerful Platforms for Deciphering Next‐Generation Therapeutics
Stereochemical and skeletal complexity are particularly important vis‐à‐vis the cross‐talks
between a small molecule and a complementary active site of a biological target. This …
between a small molecule and a complementary active site of a biological target. This …
Research progress of anticancer drugs targeting CDK12
Z Yan, Y Du, H Zhang, Y Zheng, H Lv… - RSC Medicinal …, 2023 - pubs.rsc.org
Cyclin-dependent kinase 12 (CDK12) is a transcription-associated CDK that plays key roles
in transcription, translation, mRNA splicing, the cell cycle, and DNA damage repair …
in transcription, translation, mRNA splicing, the cell cycle, and DNA damage repair …
Special Focus Issue–Targeted protein degradation: a new paradigm in medicinal chemistry
H Wall - Future Medicinal Chemistry, 2022 - Taylor & Francis
Targeted protein degradation by small-molecule degraders represents a new and exciting
mode of action in drug discovery. Proteolysis-targeting chimeras (PROTACs) represent a …
mode of action in drug discovery. Proteolysis-targeting chimeras (PROTACs) represent a …