The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Over recent years, a deeper comprehension of the molecular mechanisms that control
biological clocks and circadian rhythms has been achieved. In fact, many studies have …

Abstract Aims The Hygia Chronotherapy Trial, conducted within the clinical primary care
setting, was designed to test whether bedtime in comparison to usual upon awakening …

Aims Sleep-time blood pressure (BP) is a stronger risk factor for cardiovascular disease
(CVD) events than awake and 24 h BP means, but the potential role of asleep BP as …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications:
Controversies in Hypertension - Con Side of the Argument | Hypertension Science Volunteer …

Elevated heart rate is a risk factor for cardiovascular and all‐cause mortalities in the general
population and various cardiovascular pathologies. Insufficient heart rate decline during the …

Chronic administration of drugs leads to the activation of compensatory mechanisms that
may inhibit some of their activity and induce unwanted toxicity. These mechanisms are an …

Diagnosis of hypertension—elevated blood pressure (BP) associated with increased
cardiovascular disease (CVD) risk—and its management for decades have been based …

Accumulating evidence has indicated the potential contributions of aldosterone and
mineralocorticoid receptor (MR) to the pathophysiology of cardiovascular disease (CVD) …