Simulation and inference algorithms for stochastic biochemical reaction networks: from basic concepts to state-of-the-art

DJ Warne, RE Baker… - Journal of the Royal …, 2019 - royalsocietypublishing.org
Stochasticity is a key characteristic of intracellular processes such as gene regulation and
chemical signalling. Therefore, characterizing stochastic effects in biochemical systems is …

Weak SINDy for partial differential equations

DA Messenger, DM Bortz - Journal of Computational Physics, 2021 - Elsevier
Abstract Sparse Identification of Nonlinear Dynamics (SINDy) is a method of system
discovery that has been shown to successfully recover governing dynamical systems from …

[HTML][HTML] Modelling collective cell migration: neural crest as a model paradigm

R Giniūnaitė, RE Baker, PM Kulesa… - Journal of Mathematical …, 2020 - Springer
A huge variety of mathematical models have been used to investigate collective cell
migration. The aim of this brief review is twofold: to present a number of modelling …

Weak SINDy: Galerkin-based data-driven model selection

DA Messenger, DM Bortz - Multiscale Modeling & Simulation, 2021 - SIAM
We present a novel weak formulation and discretization for discovering governing equations
from noisy measurement data. This method of learning differential equations from data fits …

[HTML][HTML] Biologically-informed neural networks guide mechanistic modeling from sparse experimental data

JH Lagergren, JT Nardini, RE Baker… - PLoS computational …, 2020 - journals.plos.org
Biologically-informed neural networks (BINNs), an extension of physics-informed neural
networks, are introduced and used to discover the underlying dynamics of biological …

Parameter identifiability and model selection for sigmoid population growth models

MJ Simpson, AP Browning, DJ Warne… - Journal of theoretical …, 2022 - Elsevier
Sigmoid growth models, such as the logistic, Gompertz and Richards' models, are widely
used to study population dynamics ranging from microscopic populations of cancer cells, to …

Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size

PR Buenzli, M Lanaro, CS Wong, MP McLaughlin… - Acta Biomaterialia, 2020 - Elsevier
Tissue growth in bioscaffolds is influenced significantly by pore geometry, but how this
geometric dependence emerges from dynamic cellular processes such as cell proliferation …

Practical parameter identifiability for spatio-temporal models of cell invasion

MJ Simpson, RE Baker… - Journal of the …, 2020 - royalsocietypublishing.org
We examine the practical identifiability of parameters in a spatio-temporal reaction–diffusion
model of a scratch assay. Experimental data involve fluorescent cell cycle labels, providing …

[HTML][HTML] Designing and interpreting 4D tumour spheroid experiments

RJ Murphy, AP Browning, G Gunasingh… - Communications …, 2022 - nature.com
Tumour spheroid experiments are routinely used to study cancer progression and treatment.
Various and inconsistent experimental designs are used, leading to challenges in …

Revisiting the Fisher–Kolmogorov–Petrovsky–Piskunov equation to interpret the spreading–extinction dichotomy

M El-Hachem, SW McCue, W Jin… - Proceedings of the …, 2019 - royalsocietypublishing.org
The Fisher–Kolmogorov–Petrovsky–Piskunov model, also known as the Fisher–KPP model,
supports travelling wave solutions that are successfully used to model numerous invasive …