Simulation and inference algorithms for stochastic biochemical reaction networks: from basic concepts to state-of-the-art
Stochasticity is a key characteristic of intracellular processes such as gene regulation and
chemical signalling. Therefore, characterizing stochastic effects in biochemical systems is …
chemical signalling. Therefore, characterizing stochastic effects in biochemical systems is …
Weak SINDy for partial differential equations
DA Messenger, DM Bortz - Journal of Computational Physics, 2021 - Elsevier
Abstract Sparse Identification of Nonlinear Dynamics (SINDy) is a method of system
discovery that has been shown to successfully recover governing dynamical systems from …
discovery that has been shown to successfully recover governing dynamical systems from …
[HTML][HTML] Modelling collective cell migration: neural crest as a model paradigm
R Giniūnaitė, RE Baker, PM Kulesa… - Journal of Mathematical …, 2020 - Springer
A huge variety of mathematical models have been used to investigate collective cell
migration. The aim of this brief review is twofold: to present a number of modelling …
migration. The aim of this brief review is twofold: to present a number of modelling …
Weak SINDy: Galerkin-based data-driven model selection
DA Messenger, DM Bortz - Multiscale Modeling & Simulation, 2021 - SIAM
We present a novel weak formulation and discretization for discovering governing equations
from noisy measurement data. This method of learning differential equations from data fits …
from noisy measurement data. This method of learning differential equations from data fits …
[HTML][HTML] Biologically-informed neural networks guide mechanistic modeling from sparse experimental data
Biologically-informed neural networks (BINNs), an extension of physics-informed neural
networks, are introduced and used to discover the underlying dynamics of biological …
networks, are introduced and used to discover the underlying dynamics of biological …
Parameter identifiability and model selection for sigmoid population growth models
Sigmoid growth models, such as the logistic, Gompertz and Richards' models, are widely
used to study population dynamics ranging from microscopic populations of cancer cells, to …
used to study population dynamics ranging from microscopic populations of cancer cells, to …
Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size
Tissue growth in bioscaffolds is influenced significantly by pore geometry, but how this
geometric dependence emerges from dynamic cellular processes such as cell proliferation …
geometric dependence emerges from dynamic cellular processes such as cell proliferation …
Practical parameter identifiability for spatio-temporal models of cell invasion
MJ Simpson, RE Baker… - Journal of the …, 2020 - royalsocietypublishing.org
We examine the practical identifiability of parameters in a spatio-temporal reaction–diffusion
model of a scratch assay. Experimental data involve fluorescent cell cycle labels, providing …
model of a scratch assay. Experimental data involve fluorescent cell cycle labels, providing …
[HTML][HTML] Designing and interpreting 4D tumour spheroid experiments
RJ Murphy, AP Browning, G Gunasingh… - Communications …, 2022 - nature.com
Tumour spheroid experiments are routinely used to study cancer progression and treatment.
Various and inconsistent experimental designs are used, leading to challenges in …
Various and inconsistent experimental designs are used, leading to challenges in …
Revisiting the Fisher–Kolmogorov–Petrovsky–Piskunov equation to interpret the spreading–extinction dichotomy
The Fisher–Kolmogorov–Petrovsky–Piskunov model, also known as the Fisher–KPP model,
supports travelling wave solutions that are successfully used to model numerous invasive …
supports travelling wave solutions that are successfully used to model numerous invasive …