Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

Partial or complete deficiency of anterior or posterior pituitary hormone production leads to
central hypoadrenalism, central hypothyroidism, hypogonadotropic hypogonadism, growth …

Purpose Tumor immune microenvironment in pituitary neuroendocrine tumors (PitNETs) and
application of current immunotherapy for refractory PitNETs remains debated. We aim to …

Background The increased prevalence of Impulse Control Disorders (ICDs) in dopamine
agonist (DA) treated patients with Parkinson's disease is well described. Despite the …

Hypopituitarism is a highly heterogeneous multisystem disorder that can have a major
impact on long-term morbidity and mortality, but even more so during acute medical …

Due to the current limited knowledge about the role of filamin A (FLNA) in pituitary tumour
progression, we aimed to analyse FLNA expression levels and its impact on aggressive …

Mouse models of growth hormone deficiency (GHD) have provided important tools for
uncovering the various actions of GH. Nearly 100 years of research using these mouse lines …

Context Germline succinate dehydrogenase subunit B (SDHB) pathogenic variants are
characteristic of familial paraganglioma (PGL) syndrome type 4. This syndrome frequently …

Pituitary neuroendocrine tumors (pitNETs) are the second most common primary brain
tumors. Despite their prevalence, the tumor immune microenvironment (TIME) and its clinical …

Plurihormonal pituitary adenoma (PPA) is a type of pituitary tumor capable of producing two
or more hormones and usually presents as an aggressive, large adenoma. As yet, its …