[HTML][HTML] Emerging tissue engineering strategies for annulus fibrosus therapy

A Zhang, Z Cheng, Y Chen, P Shi, W Gan, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Low back pain is a major public health concern experienced by 80% of the world's
population during their lifetime, which is closely associated with intervertebral disc (IVD) …

[HTML][HTML] Regulating pyroptosis by mesenchymal stem cells and extracellular vesicles: A promising strategy to alleviate intervertebral disc degeneration

S Yang, Y Zhang, Q Peng, B Meng, J Wang… - Biomedicine & …, 2024 - Elsevier
Intervertebral disc degeneration (IVDD) is a main cause of low back pain (LBP), which can
lead to disability and thus generate a heavy burden on society. IVDD is characterized by a …

[HTML][HTML] The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing …

J Zhu, R Sun, K Sun, C Yan, J Jiang, F Kong, J Shi - Redox biology, 2023 - Elsevier
Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main
contributor and independent risk factor for low back pain (LBP), it would be, therefore …

Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway

S Tian, X Chen, W Wu, H Lin, X Qing, S Liu… - … & Molecular Medicine, 2024 - nature.com
Lower back pain (LBP), which is a primary cause of disability, is largely attributed to
intervertebral disc degeneration (IDD). Macrophages (MΦs) in degenerated intervertebral …

Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration

Y Tang, K Zhang, H Zhou, C Zhang, Z Liu… - Journal of …, 2023 - Springer
Background Cell transplantation has been demonstrated as a promising approach in tissue
regeneration. However, the reactive oxygen species (ROS) accumulation and inflammation …

Emerging role and therapeutic implications of p53 in intervertebral disc degeneration

Y Wang, S Hu, W Zhang, B Zhang, Z Yang - Cell Death Discovery, 2023 - nature.com
Lower back pain (LBP) is a common degenerative musculoskeletal disease that imposes a
huge economic burden on both individuals and society. With the aggravation of social aging …

Catalytic Nanodots‐Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration

K Sun, C Yan, X Dai, Y Shi, F Li, L Chen… - Advanced …, 2024 - Wiley Online Library
Low back pain resulting from intervertebral disc degeneration (IVDD) is a prevalent global
concern; however, its underlying mechanism remains elusive. Single‐cell sequencing …

Understanding necroptosis and its therapeutic target for intervertebral disc degeneration

Z Wang, X Hu, W Wang, Y Li, P Cui, P Wang… - International …, 2023 - Elsevier
Intervertebral disc degeneration (IVDD) is a complex pathological condition associated with
the development of low back pain. Despite numerous studies, the specific molecular …

Sensory nerve regulation of bone homeostasis: emerging therapeutic opportunities for bone-related diseases

Y Chen, B Guo, G Ma, H Cao - Ageing Research Reviews, 2024 - Elsevier
Understanding the intricate interplay between sensory nerves and bone tissue cells is of
paramount significance in the field of bone biology and clinical medicine. The regulatory role …

褪黑素抑制过氧化氢诱导人髓核细胞的损伤

谢文冠, 刘宇涛, 崔文波, 邝铭业 - 中国组织工程研究, 2024 - cjter.com
褪黑素抑制过氧化氢诱导人髓核细胞的损伤 Page 1 2180|中国组织工程研究|第28卷|第14期|2024年
5月 中国组织工程研究 Chinese Journal of Tissue Engineering Research www.CJTER.com …