Executive summary Around the world, populations are ageing at a faster pace than in the
past and this demographic transition will have effects on all aspects of societies. In May …

Alzheimer's disease (AD) is prevalent throughout the world and is the leading cause of
dementia in older individuals (aged≥ 65 years). To gain a deeper understanding of the …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

A growing awareness about brain health and Alzheimer's disease in the general population
is leading to an increasing number of cognitively unimpaired individuals, who are concerned …

Fatigue has been defined differently in the literature depending on the field of research. The
inconsistent use of the term fatigue complicated scientific communication, thereby limiting …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …

This article reviews the cognitive changes that occur with normal aging, the structural and
functional correlates of these cognitive changes, and the prevalence and cognitive effects of …

As the worldwide population ages, oncologists are often required to make difficult and
complex decisions regarding the treatment of older people (aged 65 years and older) with …